His early work was influenced by the architectural style of his former employer, including Italianate and Greek revival buildings.
During this period he worked on numerous residential villas, and several public buildings including the Queens Rooms (1856) and the Free Church College (1856–1857), both in Glasgow.
Wilson's former assistant, David Thomson, returned to his firm as a partner shortly after, taking on the running of the practice.
In February 1863 Charles Wilson died of dropsy, and was buried in Glasgow's Southern Necropolis, close to the gateway he had designed in 1848.
[1] A House designed by Charles Wilson plays an important part in the "Empathy is the Enemy" storyline of the comic-book series Hellblazer.