Charlestown is a suburb of the City of Lake Macquarie, New South Wales, Australia, and the largest suburb in Lake Macquarie and in the Greater Newcastle area.

It is approximately 10 kilometres (6 mi) west-south-west of the central business district of Newcastle.

Charlestown Square is a large shopping centre located just off the Pacific Highway.

Charlestown features clusters of shops along Pacific Highway as well as in surrounding streets.

New South Wales Ambulance has its Northern Communications Centre in the suburb, off Dudley Road.