[6] In May 2020 a new one-off episode entitled Antiviral Wipe was broadcast, which was filmed in lockdown due to the COVID-19 pandemic.

Weekly Wipe features Al Campbell as "Barry Shitpeas" and Diane Morgan as "Philomena Cunk" (Cunk being portrayed as a deliberately dim-witted/ill-informed interviewer), and segments by comedians Doug Stanhope, Tim Key, Limmy, Jake Yapp, Catriona Knox as reporter "Emily Surname" and Morgana Robinson.

[2] In the first series, alongside these contributors, guest stars such as Richard Osman and Susan Calman joined Brooker in a chat show segment, discussing recent events of interest.

[8] The programme includes segments used by Brooker in his year-in-review wipes, such as the "World of Bullshit" section; these short clips cover the more mundane elements of otherwise newsworthy events.

As with much of Brooker's work, Weekly Wipe openly mocks other shows, people, and news events.