[1] Charlie runs the titular Hazbin Hotel, where she hopes to redeem the souls of those in Hell and help them earn a place in Heaven.

She is bubbly and upbeat and announces her "Happy Hotel", intended to redeem sinners to allow them to go to Heaven in a televised interview with newscaster Katie Killjoy.

The interview ends in a fight between her and Katie, but this attracts the attention of Alastor "the Radio Demon", who visits her in the aftermath and offers his help in running the hotel.

In "Radio Killed the Video Star", she is shown to be very forgiving, as after Sir Pentious enters the hotel and is exposed for being a spy for Vox, Charlie takes pity on him and gives him a second chance.

In "Hello Rosie", after making a deal with Alastor, she is shown to be most successful in speaking and rallying crowds of people when she is singing, and she convinces the citizens of Cannibal Town to fight with her against the angels in the next Extermination.

The music video followed Charlie as she pitched the titular hotel to newscaster Katie Killjoy and the rest of Hell in a song.

[25] Charlie makes a silent cameo appearance in the 2020 music video for the song "Addict", in which she outstretches a hand to Angel Dust as he walks away after a tough day at work with Valentino.

The latter song was described as a "farewell" to the pilot cast voice actors, having been written a year prior (following the announcement that A24 would be re-casting), and released the day after the premiere of "Overture" as "a light-hearted and proverbial passing of the torch".

[28][29] From 2019 to 2023, Jill Harris and Elsie Lovelock would reprise their roles as Charlie in a series of skits in HuniCast, a live podcast series co-hosted by Angel Dust's pilot voice actor, Michael Kovach, and Hazbin Hotel pilot animator Ashley Nichols, which often featured the cast and crew of Hazbin Hotel and SpindleHorse Toons as guests.

From 2020 to 2021, Charlie appeared in a series of augmented reality "Voxtagram" posts published to Instagram by SpindleHorse Toons, depicting her as running the hotel's social media account with Vaggie in a slice-of-life style.

Esther Liberman of BeLatina described her as "redeemable and empathetic", and argued that the show's pilot demonstrated Charlie's biculturalism, with a "subtle analog to her flexible sexuality".

Hope Mullinax of Collider praised her "joyous" showstopping musical numbers,[2] while Screen Rant complimented her "high energy pop beats" and "go-getter attitude",[3] calling her "the heart and soul of Hazbin Hotel" without whom "the show would be very grim and somewhat pointless".

[4] Rachel Leishman of The Mary Sue argued that the series is "charming" because of Charlie's hopeful nature, which inspires her girlfriend Vaggie.

[38] Since 2018, official clothing and merchandise based around Charlie and the cast of Hazbin Hotel designed by Medrano have been available intermittently from Shark Robot LLC.