He also served as an offensive coordinator in the National Football League (NFL) for the New York Jets, New England Patriots, and Kansas City Chiefs.

After graduating from Notre Dame in 1978, Weis began his coaching career at Boonton High School in New Jersey.

He spent the next five seasons at perennial powerhouse Morristown High School in New Jersey as a football assistant developing players such as Michael Landsberg.

The Giants went on to win Super Bowl XXV at the end of that season, beating the Buffalo Bills by a score of 20–19.

In 1995, Weis helped turn rookie Curtis Martin's year into a Pro Bowl season with 1,487 yards and 14 touchdowns on the ground.

[3] On November 30, 2004, after finishing its football season with a 6–5 record, Notre Dame released head coach Tyrone Willingham.

[11][12] His team's success on the field helped make Weis winner of the 2005 Eddie Robinson Coach of the Year Award, selected by the Football Writers Association of America.

[21][22] Their loss to Navy on November 3 snapped an NCAA-record 43-game winning streak over the Midshipmen, dating back to the Heisman Trophy-winning tenure of Roger Staubach at the Naval Academy.

[30] In 2008, The Irish started 4–1, but completed the regular season with a 6–6 record, including a 24–23 loss to Syracuse, the first time that Notre Dame had fallen to an eight-loss team.

[31] Weis's Notre Dame squad ended the season on a positive note, finally breaking the Irish's NCAA record nine-game bowl losing streak by beating Hawaii 49–21.

In Weis's first year, the Chiefs improved from a record of 4–12 to 10–6 and returned to the playoffs after winning the AFC West Division.

With Weis as offensive coordinator, the Chiefs had the NFL's best rushing attack, averaging an impressive 165 yards per game on the ground.

However, the Chiefs also sent four players on offense (WR Dwayne Bowe, RB Jamaal Charles, QB Matt Cassel and OG Brian Waters) to the Pro Bowl.

On December 31, 2010, ESPN reported that Weis was targeted by the Florida Gators to become the next offensive coordinator under new head coach Will Muschamp.

[35] On January 2, 2011, Chiefs coach Todd Haley announced Weis would indeed be leaving for the Florida offensive coordinator position effective at the end of the season.

On December 8, 2011, Weis was named the head football coach for the University of Kansas replacing Turner Gill.

Although they only compiled a 3–9 record, Weis' Jayhawks ended a 27-game Big 12 Conference losing streak with a 31–19 home victory over West Virginia in November 2013.

In 2003, Weis and his wife established the Hannah & Friends Foundation, dedicated to children affected by developmental disorders and named after his daughter, who is autistic.

He was there to celebrate the announcement of the Notre Dame and Army football game to be played at the new Yankee Stadium in November 2010.

A major reason cited for the jury's decision is that Weis ignored doctors' advice and pushed to have the operation done quickly, rather than going through a recommended six-week preoperative program.

[46] During a game against Michigan on September 13, 2008, Notre Dame defensive end John Ryan accidentally collided with Weis on the sideline.