[1] On June 14, 1979, the musical opened titled Flowers for Algernon at Queen's Theatre in the West End with Michael Crawford as Charlie.
The audience reaction to this was so positive that Crawford repeated it with another live mouse (while playing an entirely different character) in 2003 while starring in the West End musical The Woman in White.
[3][4] Directed by Louis W. Scheeder and choreographed by Virginia Freeman, the cast featured P. J. Benjamin (Charlie) and Sandy Faison.
In October 2016, Marymount Manhattan College and The York Theatre Company mounted a staged musical reading of the original "Charlie and Algernon", directed by composer Charles Strouse's spouse, Barbara Siman, and featured Ian Morel, Mia Massaro, Alex Burnette, and Brent Jones.
[6] Charlie volunteers to participate in an experimental intelligence-enhancing treatment, and his rapid progress parallels that of Algernon, who had been treated earlier.