[3] She studied painting at the Hochschule für bildende Künste of Hamburg under Jörg Immendorff, and at the Kunstakademie Düsseldorf under Fritz Schwegler.
[5][3] Since 1997, Charline von Heyl has been married to fellow artist Christopher Wool.
In 2005, von Heyl's exhibition Concentrations 48: Charline von Heyl[6] was held at the Dallas Museum of Art in Dallas, Texas, USA, and in 2009, her work was exhibited in Le jour de boire est arrivé held at Le Consortium, a contemporary art center in Dijon, France.
[11] Featuring more than thirty large-scale paintings, Charline von Heyl: Snake Eyes was extended due to its popularity at the museum.
In 2024, von Heyl was among the 18 artists selected by the Port Authority of New York and New Jersey to create installations for John F. Kennedy International Airport’s new Terminal 6, set to open in 2026.