Hope gained further prominence in the lead role of Catherine of Aragon on the Starz historical drama series The Spanish Princess (2019–2020).

Hope headlined the Showmax true crime series Catch Me a Killer as South African profiler Micki Pistorius in 2024.

Upon graduation from Oxford, Hope spent a year in Paris training in acting at L'École Internationale de Théâtre Jacques Lecoq.

[6] In 2013, Hope began playing the role of Ramsay Bolton's sadistic lover, Myranda, in HBO's fantasy drama series Game of Thrones.

[12] In March 2018, Hope was cast in the lead role of the Starz series The Spanish Princess, in which she plays Catherine of Aragon.

[14] Having worked with Danish director Birgitte Stærmouse on the first season of The Spanish Princess, the pair teamed up again for Netflix's miniseries The English Game, which also aired in 2020.