[5] She said that she and her siblings could choose how involved in politics they would be;[5] Pence told Ben Shapiro in an interview in 2018 that as children they could be included in an event only if they wanted to.

[7]:1[9]:31 Pence spent her junior year at DePaul University studying a semester in English and Philosophy abroad at St Catherine's College, Oxford.

[10][11] At DePaul, Pence was involved with the school ministry, a student group that addresses violence in Chicago, and creative writing and film communities; she worked on documentary projects, one of which won nine regional Emmy Awards, and joined the Chi Omega sorority.

[19] She described her lifestyle changes after her father became Trump's running mate in July, writing, "I went from taking public transit in Chicago to riding in a presidential motorcade in the span of just a few months.

"[6] Early August 2016, Pence started travelling around the U.S. with her father on his campaign trail, which included the 2016 Republican National Convention in Cleveland, Ohio.

[5] Pence's recent graduation gave her time to travel the country and she joked that her role on the campaign trail was to "babysit her parents".

[22]:1 Pence described herself politically as "more of a moderate or independent" and said that she does not always agree with the policies of her father and Trump, adding "I think I have views that go across the board", which she says has been encouraged by her parents.

"[23][9]:29 Since the inauguration, Pence helped provide a "support system for her parents", without taking official roles, while working full-time in Washington, D.C. at a film production company.

[25][7]:2 Pence created an Instagram account for Bundo "right after [her] dad was inaugurated [Vice President]", "not knowing if anybody would follow it".

[26] Pence and her mother thought about creating a children's book, following Bundo's popularity on Instagram and because Karen is a watercolor painter.

[24][29] Proceeds from the picture book go to benefit art therapy programs, and The A21 Campaign, which works to combat human trafficking;[30] Charlotte Pence picked the latter charity because of her prior experience with the organization.

[31] As a "jab" at Mike Pence's opposition to LGBT rights in the United States, a parody of the picture book titled A Day in the Life of Marlon Bundo, authored by Last Week Tonight with John Oliver's comedy writer Jill Twiss and illustrated by Gerald Kelley, was published by Chronicle Books a day before.

[33] Proceeds from the parody book go to benefit The Trevor Project, which runs a crisis hotline for members of the LGBTQ community, and AIDS United.