Valandrey's debut film was Véra Belmont's 1985 political drama Red Kiss, in which she played Nadia.

Her highly acclaimed performance as a young communist in 1950s Paris was rewarded with a César award nomination for "Most Promising Actress" the following year but she eventually lost to Charlotte Gainsbourg.

In her book L'Amour dans le sang (published in 2005), she recounts her other love stories, with her cardiologist or Yann, an architect whom she intimately believes to be the husband of her late donor.

[clarify] In March 2007, after selling over 280,000 copies of her book, Charlotte gave approval for its adaptation in the TV movie, L'Amour dans le sang.

Charlotte was a patron of the Greffe de vie ("Foundation of Life Registry") and was committed to the cause of organ donation and transplantation.