[1] D'Amboise made her Broadway debut in the musical Cats in 1984 as Cassandra,[2][3] where she met her future husband, performer Terrence Mann.
[4] She frequently has played the role of Roxie Hart in Chicago, first heading the 1997 national tour and later joining the Broadway revival cast in 1999.
[10] She originated the role of Fastrada in the 2013 Broadway revival of Pippin, alongside her husband Terrence Mann, who played Charles.
Her film credits include The In Crowd (1988), American Blue Note (1989), Just Off the Coast (1992) and The Preacher's Wife (1996).
On television, she has appeared in the Kennedy Center Honors (1989, 1995 and 2002), Law & Order (2001), One Life to Live (2009), and a videotaped performance of the Broadway musical Contact (2002).