[3] They had the following children: The couple maintained residences at 148 Piccadilly and Gunnersbury Park in London where, in the tradition of the English family, she used the style "de" Rothschild.

Charlotte Freifrau de Rothschild became one of England's most prominent socialites whose dinner invitations, according to biographer Stanley Weintraub, were favoured over those from Buckingham Palace.

In 1844, the Freifrau caused a sensation in London society when the American showman P. T. Barnum and his celebrated midget "Tom Thumb" performed at her home.

However, beyond socializing and entertaining, Charlotte von Rothschild was a dedicated patron of numerous charities with a special interest in education.

Following her death, her eldest son named a newly constructed block of housing for low-income persons "Charlotte's Buildings.