Chartiers Creek is a tributary of the Ohio River in Western Pennsylvania in the United States.

Chartiers Creek winds from its headwaters in Washington County through Allegheny County, where it meets the Ohio River at McKees Rocks and Pittsburgh's West End, three miles west of the Point at Pittsburgh.

(Mouth at the Ohio River) Acid mine drainage, agricultural and industrial runoff, and sewer overflow made Chartiers Creek one of the most polluted watersheds in Pennsylvania.

In 2020, the South Fayette Conservation Group started a project that will treat the polluted water before it enters Millers Run.

This will result in Miller’s Run running clear from Cecil to Bridgeville for the first time in generations, while eliminating the single biggest source of pollution along Chartiers Creek [1] Plans have been considered[11][12] to establish the course of Chartiers Creek as a greenway including a multi-use path that would stretch from Canonsburg Lake to the Ohio River.