Since 2010, Masterson has reprised her role as Leeta from Deep Space Nine, both in hologram form and in her "mirror universe" guise, in Cryptic Studios' Star Trek Online.

In addition, she has released several independent jazz CDs: Thrill of the Chase, whose title is a play on her stage name, the follow-up EP AD ASTRA!

"[17][5][6] In 2004, as a result of her genre work, Masterson was named one of the world's "50 Sexiest Women" by the men's magazine Femme Fatales,[18] and the "Favorite Science Fiction Actress on Television" in a TV Guide reader's poll.

[19] In December 2009, AOL named her one of the "Ten Sexiest Aliens on TV", reporting that Masterson is "regularly voted the most popular guest at Star Trek conventions.

"[20] Following a series of stalking incidents instigated by a man in Berlin, Masterson – under her birth name of Christianne Carafano – was the petitioner in Carafano v. Metrosplash.com, an online dating service, formerly Matchmaker.com, on which the man had created a fictitious dating profile that contained Masterson's home address, telephone number, four photographs of her, and a description of her that characterized her as licentious.

The United States Court of Appeals for the Ninth Circuit ruled against Masterson, deciding the man who created the profile was responsible for it, and not Matchmaker.com.