[7] After graduating from Northeastern in 2010, Strangio received a fellowship from the Sylvia Rivera Law Project (SRLP) to continue developing his legal skills.

[4][5] He was also part of the team suing on behalf of trans student Gavin Grimm, who was denied access to the boys' restrooms at his school.

[4][10] In October 2019, Strangio was one of the lawyers representing Aimee Stephens, a trans woman who was fired from her job at a funeral home, in the U.S. Supreme Court case R.G.

[11][12] The previous month, trans actress Laverne Cox brought Strangio as her date to the 2019 Emmy Awards, and the pair spoke to reporters on the red carpet about the upcoming court case.

[16][17] In November 2020, journalist Glenn Greenwald criticized Strangio's comments about the book Irreversible Damage: The Transgender Craze Seducing Our Daughters by Abigail Shrier.

[20] Strangio has appeared on television programs including The Rachel Maddow Show,[21] Democracy Now!,[22] For the Record with Greta,[23] AM Joy,[24] PBS NewsHour,[25] and Up.

[28][29] In the days ahead of oral arguments, Strangio published an op-ed in the New York Times describing how having access to the forms of gender-affirming medical care prohibited by the Tennessee law saved his own life.