Chauncey Depew Leake (September 5, 1896 – January 11, 1978) was an American pharmacologist, medical historian and ethicist.

Leake received a bachelor's degree with majors in biology, chemistry, and philosophy from Princeton University.

Leake married the microbiologist Elisabeth Wilson in 1921, and they collaborated for many years.

One of his publications was a translation of the 1628 physiological work De motu cordis (On the Motion of the Heart) from Latin to English.

[7] A collection of his papers is held at the National Library of Medicine in Bethesda, Maryland.