[1] It has been broadcast live on Saturdays and Sundays on the Italian TV since 2003.

In May 2023, public broadcaster RAI decided to not renew the show for a new season.

Current events, political, economic, sporting, musical, literary, cinematic, scientific, nature and environmental issues of topical interest are discussed.

[2] Through years the show hosted many Italian and international guests.

Amongst them there are: Pope Francis, Mikhail Gorbachev, John Landis, Bill Gates, Coldplay, Mark Knopfler, Kylie Minogue, Oasis, Cherie Blair, Condoleezza Rice, Pedro Almodóvar, Hugh Grant, Vandana Shiva, Tony Blair, Phil Collins, Robert Plant, Annie Lennox, Ricky Martin, Zygmunt Bauman, Lou Reed, James Taylor, Penélope Cruz, Diego Armando Maradona, Jean Dujardin, Matt Damon, George Clooney, Stromae, Novak Đoković, U2, Jane Fonda, Madonna, Noel Gallagher, Yanis Varoufakis, Adele, Charlize Theron, Dua Lipa, Russell Crowe, Ryan Gosling, LP, Tony Hawk, Naomi Campbell, Ed Sheeran, Olivia O'Brien, Carl Lewis, Anastacia, Vincent Cassel, Lewis Hamilton, Tom Hanks, Meryl Streep, Boris Becker, Alice Merton, Alain Delon, Rowan Atkinson, Michael Bublé, Emmanuel Macron, Jean-Claude Juncker, John Travolta, Ron Howard, John Bercow, Uma Thurman, Charles Leclerc, Sebastian Vettel, Anthony Fauci, Ken Follett, Whoopi Goldberg, Dan Brown, Greta Thunberg, Michael Houghton, Glenn Close, Robbie Williams, Susan Sarandon, Barack Obama, Nancy Pelosi, Pelé, Matthew McConaughey, Woody Allen, Sharon Stone, Brian May, Quentin Tarantino, Lady Gaga, Christine Lagarde, Roberta Metsola, Sean Penn, Jens Stoltenberg, Carlo Rovelli, Rafael Nadal, Richard Gere, Austin Butler, Magic Johnson, Timothée Chalamet, Daniel Pennac, Emmanuel Carrère, Ben Affleck, Steve Martin, Anthony Hopkins, David Grossman, Willem Dafoe, Wim Wenders, Martin Scorsese, António Guterres, Josh O'Connor, Mike Faist, Zendaya, Ursula von der Leyen, Pep Guardiola, Al Pacino, Johnny Depp, Sting and Angela Merkel.