He is considered the founding father of Francophone Lebanese literature, and his literary work was overtly political, becoming most manifest in his poetry collection Ronces et Fleurs (Brambles and Flowers).

[2] In the following years he became a dynamic political activist and leader, liaising with powerful regional and international players, such as the Maronite Patriarch Elias Peter Hoayek, Lebanese separatists, and Arab nationalists.

[7][8] Ganem welcomed the Young Turk Revolution of July 1908, wrongly assuming that it would relieve the Arab provinces suffering under Sultan Abdul Hamid II rule.

The organization's goals were to promote relations between France and the Ottoman Empire, and to circulate news about the Near East through the society's bulletin, the Correspondance d'Orient.

His goals matched those of the committees established by Lebanese diaspora press figures, such as Naoum Mokarzel and Asad Bishara in New York and São Paulo respectively.

Ganem and Samné coordinating the efforts of the Lebanese-Syrian diaspora through the Central Syrian Committee, which they created with the support of the French Ministry of Foreign Affairs in 1916.

The organization, became a rallying point for Lebanese and Syrian emigrants in Dakar, Conakry, Montreal, Manchester, Sydney, New York, Santiago de Chile and São Paulo who sought the independence, and territorial integrity of Greater Syria.

[7][5] He published his first novel, Daad in 1909,[2] and wrote Antar his theatrical fantasy masterpiece, named after Antarah ibn Shaddad, a pre-Islamic Arab knight and poet, famous for both his poetry and his adventurous life.

[2] Gabriel Dupont adapted the theatrical piece into an opera, which was hailed by the critics at its premiere in 1921 at the Théâtre National de l'Opéra.

[3][13][15][16] According to French and Francophone studies expert Martine Sauret, Antar "... was considered the most important event of Arabic nationalism organized abroad".