The medical centre moved to the Old Manor House at Lisson Green in Marylebone in 1813[5]: 20  where it was completely rebuilt to a design by Charles Hawkins in 1856.

[6][7] Maternal death was a common occurrence in London throughout the 19th and 20th centuries, especially among healthy young women who were in good health prior to their pregnancies.

[8] One specific cause of maternal death, postpartum infection (then known as childbed fever, and now also as puerperal sepsis), was referred to as the doctor's plague, because it was more common in hospitals than in home births.

The unit is known as the de Swiet Obstetric Medicine Centre, and is currently housed in a small suite of rooms on the second floor of the Queen Charlotte's and Chelsea Hospital.

[21] The delivery suites in the labour ward offer women a more traditional childbirth experience, while the birth centre strives to create a more "homely" environment.

[21] In addition to the birth centre, Queen Charlotte's and Chelsea Hospital also offers a relatively new programme called the "Jentle Midwifery" scheme.

[25] Queen Charlotte's and Chelsea Hospital sent 800 families home with foam mattresses inside of cardboard boxes for their newborn children.

[25] Today, Queen Charlotte's and Chelsea Hospital is the home of several ongoing research projects through the Imperial College Healthcare National Health Service (NHS) Trust.

[26] COSMIC is an independent charity supporting the work of the neonatal and paediatric intensive care services of Imperial College Healthcare NHS Trust, London.

The charity funds a range of specialist equipment for the units, including patient monitoring systems and sensory play stations for those being treated on the wards.