Approximately 8,000 journals, technical reports, dissertations, conference proceedings, and new books, available in at least 50 different languages, are monitored yearly, as are patent specifications from 27 countries and two international organizations.

Originally it was available only as a client application (for both Windows and MacOS operating systems), a web version was released in 2008.

[citation needed] SciFinder Scholar was a very similar a product developed for academic institutions, but discontinued in 2023.

[6][7] In 2017 the ACS released SciFinder-n as a web-only product with the same data content and improved user interface and search functions.

[9] However, due to its unique and unusual search functions, substantial training is needed in order to fully take advantage of SciFinder capabilities.

The online CASSI Search Tool provides titles and abbreviations, CODEN, ISSN, publisher, and date of first issue (history) for a selected journal.

[11] Beyond CASSI lists abbreviated journal titles from early chemical literature and other historical reference sources.

[14] In 1965, CAS moved to a new 50-acre (200,000 m2) site on the west bank of the Olentangy River, just north of The Ohio State campus.

Ground was broken in 1971 for an expansion to the building designed by architects Brubaker/Brandt to accommodate the review of 400,000 new research reports printed each year.

The organization updated their mission to be more focused on dynamic responsiveness due to ongoing changes within scientific industries and communities.