In 1922, voters approved a proposal to demolish the 1898 high school building and replace it with a larger structure.

Local architect Rockwell A. LeRoy designed a classroom building and auditorium that would connect to the 1912 gymnasium.

[6] Old Central High School is a four-story Tudor Revival structure with an E-shaped facade.

Located on the fourth floor of the Old Central High School building, KAMSC's main purpose is to provide accelerated learning in mathematics and science to qualifying students in the Kalamazoo area selected through a yearly application process.

Filling the math and science requirements for each student, students attend the remainder of their classes at public and private schools all over Kalamazoo County, with the primary applicant pool stemming from the Kalamazoo Regional Educational Service Agency (KRESA); while the school itself is under the authority of KPS, its students are not required to attend a KPS high school in tandem with KAMSC.