The two schools would be centered in the western and eastern ends of the county, to service the county's two main population centers: Rogersville-Bulls Gap- Mooresburg and Church Hill-Mount Carmel-Surgoinsville.

[5] The initial choice for the first principal chose not to take the job, so Ralph Anderson, the former superintendent of the county school district, was chosen.

So that these populations would still be served under the new plan, the Board of Education purchased land as equidistant from Rogersville and Bulls Gap as possible.

[9] The school's mascot was derived from the old Rogersville High Warriors; its colors were taken from the orange and black of the old Bulls Gap High and the maroon and grey of the old Rogersville, to derive the red and black Cherokee Chiefs.

Men's and women's varsity, junior varsity, and freshman teams compete in the Tennessee Secondary School Athletics Association Division I in the following classifications:[10] Region 1 There are 6 classes in Tennessee, with 8 regions per class.

Cherokee High School is one of the locations in the novel series "The Living Saga" by Jaron McFall.