The Cherokee Triangle is a historic neighborhood in Louisville, Kentucky, USA, known for its large homes displaying an eclectic mix of architectural styles.

Its boundaries are Bardstown Road to the southwest, Cherokee Park and Eastern Parkway to the southeast, and Cave Hill Cemetery to the north, and is considered a part of a larger area of Louisville called The Highlands.

The first house in the neighborhood, located at the corner of Transit Avenue (now Grinstead Drive) and New Broadway (now Cherokee Road), was completed in 1871 as a wedding present for Henning's daughter.

Henning and Speed sold lots briskly for an average of $1,200 each, between 1870 and 1873, but development virtually halted in Cherokee Triangle and everywhere else after an economic depression known as the Panic of 1873.

Many wealthy residents left for new suburbs after World War II, and as was typical of older affluent neighborhoods such as Old Louisville, large multi-story buildings were split up into inexpensive apartments.

Largely as a result of the preservation district status, the neighborhood has undergone a period of sustained gentrification and enjoyed the greatest appreciation in property values in the city over the past decade.