Cherry Mix's second season began when he finished third when favourite for the Listed Prix Maurice Caillault over 2100 metres at Saint-Cloud Racecourse on 18 March.
The horses finishing behind him included Ouija Board, North Light, Tap Dance City, Warrsan, Blue Canari, Pride and Grey Swallow.
[7] Before the start of the 2005 season Cherry Mix was acquired by Sheikh Mohammed's Godolphin organisation and was transferred to the stable of Saeed bin Suroor.
[8] After an absence of more than five months Cherry Mix returned to the track in Germany on 4 September when he was made favourite for the Grosser Preis von Baden but finished fifth of the nine runners behind Warrsan.
Two weeks after his failure at Longchamp the colt was sent to Italy and started the 1.6/1 favourite for the Gran Premio del Jockey Club over 2400 metres at San Siro Racecourse in Milan.
On returning to Europe he was unplaced in the Yorkshire Cup in May and then finished last of the six runners behind Hurricane Run in the King George VI and Queen Elizabeth Stakes at Ascot Racecourse in July.
On 15 October he attempted to repeat his 2005 success in the Gran Premio del Jockey Club but after leading for most of the way he was overtaken approaching the last 200 metres and finished third behind Laverock and Fair Nashwan.
At Capannelle Racecourse in Rome over 2000 metres on 5 November the horse was ridden by Ted Durcan and started at odds of 3.4/1 in a ten-runner field for the Premio Roma.
The German horse Soldier Hollow, winner of the race for the last two years started favourite, while the other runners included Fair Nashwan, Distant Way (Premio Presidente della Repubblica), Emily Bronte (Prix des Réservoirs) and Hattan (Chester Vase).
He finished fourth to Distant Way in the Premio Presidente della Repubblica at Rome in May and was then stepped up in distance a month later for the Ascot Gold Cup in which he came home eighth behind Yeats.