The Cherry Street Historic District is a historic neighborhood, commercial, and entertainment district serving as the downtown of Helena in Helena–West Helena, Arkansas.

The history of Cherry Street is tied to the blues heritage of the area beginning in the 1940s.

Around the time of incorporation of West Helena in 1917, the lumber industry was the primary economic force in the region, with five companies producing barrel staves being the primary employers.

This radio show helped spread the growing sensation of blues music and popularized many blues pioneers such as Robert Lockwood, Jr., Robert Lee McCollum, and Sonny Boy Williamson II.

Cherry Street has hosted the King Biscuit Blues Festival annually since 1986, under various names.