Cherry Tree is a borough in Indiana County, Pennsylvania, United States.

The current name was officially adopted in 1907 but had been in use informally by local residents for many years before that time.

[4] The tree marked the eastern boundary of the territory acquired by the Penn family from the Six Nations of the Iroquois at the Treaty of Fort Stanwix on November 5, 1768.

The boundary, called the "purchase line", extended from the cherry tree westward to the current site of Kittanning on the Allegheny River.

According to the United States Census Bureau, the borough has a total area of 0.5 square miles (1.3 km2), all land.

Cherry Tree is served by the Harmony Area School District.