[2] Boone Isaacs was the first African American to hold this office, and the third woman (after Bette Davis and Fay Kanin).

[3][4] On November 16, 2021, it was announced that Boone Isaacs would serve as Founding Director of the Sidney Poitier New American Film School at Arizona State University's Herberger Institute for Design and the Arts, effective January 1, 2022.

Boone Isaacs was then Director of Advertising and Publicity for The Ladd Company and worked to promote films like The Right Stuff and Once Upon a Time in America.

[10] As Paramount's Executive Vice President of Worldwide Publicity, she orchestrated the marketing campaigns for Best Picture winners Forrest Gump and Braveheart.

[8]: 200 From 1997 to 1999, she was President of Theatrical Marketing for New Line Cinema, where she promoted Austin Powers: The Spy Who Shagged Me, The Wedding Singer and Boogie Nights.

[16] Boone Isaacs started her own company, called CBI Enterprises, Inc., where she worked on publicity for films that included Best Picture winners The King's Speech and The Artist.

[17] As President of the AMPAS, Boone Isaacs was instrumental in removing the restriction of the number of members allowed into the Academy, what had been a long-time membership cap.

[10] Boone Isaacs has been an active force in addressing the lack of diversity,[18][19] and an imbalance of membership that is predominantly white and male.