Chesapeake is an unincorporated community and census-designated place in Lawrence County, Missouri, United States.

[2] It is located on Route 174, approximately five miles east of Mount Vernon.

Chesapeake currently houses a fish hatchery, operated by the Missouri Department of Conservation.

A post office called Chesapeake was established in 1850, and remained in operation until 1914.

This Lawrence County, Missouri state location article is a stub.