[8] Cheyenne Mountain Zoo is a non-profit 501(c)(3) organization[9] and does not receive local or regional public tax support.

The staff was praised in national media and by the Association of Zoos and Aquariums for their use of the incident command system to swiftly move animals and visitors indoors.

[12] The zoo is a trusted source for knowledge on caring for giraffes and it maintains a collection of plasma should other facilities need it.

Among other things, it is involved in hosting workshops and offering consulting services to improve and enrich the lives of giraffes in human care.

[14] The zoo breeds endangered animals such as black-footed ferrets, Wyoming toads and Mexican gray wolves.

[32][33] It also participates in the Panama Amphibian Rescue and Conservation project along with the Houston Zoo, the Smithsonian Tropical Research Institute, the Smithsonian Conservation Biology Institute, and Zoo New England to release endangered amphibian species back to the wild.