The station was designed to support economic development and the transportation of agricultural goods from the region to markets in Eastern Europe and Russia.

In 1918, the railway was heavily used by members of the Sfatul Țării, particularly for connections to Iași, where the Romanian Government and the Royal House had been evacuated from Bucharest following the German occupation.

On January 6 1918, the Bolshevik Front Section arrested a detachment of soldiers from Transylvania at the Chișinău station[3], who, according to a preliminary agreement, had arrived from Kiev under the orders of the Sfatul Țării.

The Romanian Prime Minister held talks with members of the Bessarabian government, representatives of factions in the Sfatul Țării, clerics, large landowners, and other social groups to understand their stance on the union of Bessarabia with Romania.

After World War II, following the destruction caused by the conflict, the station was rebuilt in Stalinist style, although some original architectural elements were preserved.