The Chicago Great Western Railroad-Waterloo Freight Depot is a historic building located in Waterloo, Iowa, United States.

In 1903 the railroad built new passenger and freight depots a block south, moving them closer to the city's wholesale houses.

The concrete block addition on the southeast side replaced a frame gabled structure, but its construction date is unknown.

[1] In 2001 the building, which is owned by the City of Waterloo, was leased to the University of Northern Iowa for its Center for Urban Education (UNI-CUE).

This article about a property in Black Hawk County, Iowa on the National Register of Historic Places is a stub.