It stars Nick Gehlfuss, Yaya DaCosta, Torrey DeVitto, Rachel DiPillo, Colin Donnell, Brian Tee, S. Epatha Merkerson, Oliver Platt, Marlyne Barrett, Norma Kuhling, Dominic Rains, Steven Weber, Guy Lockard, Kristen Hager, Jessy Schram, Luke Mitchell, Sarah Ramos and Darren Barnet, it premiered on November 17, 2015.

It focuses on the emergency department at Gaffney Chicago Medical Center and on its doctors and nurses as they work to save patients' lives.

[4][5] The Walking Dead star Laurie Holden was originally cast as Dr. Hannah Tramble, but dropped out due to "family reasons".

[42] In July 2015, Jurassic World star Brian Tee joined the cast as Dr. Ethan Choi, an expert in infectious disease prevention and a Navy Reserve medical officer.

[44] On August 14, 2015, Jane the Virgin star Rachel DiPillo was cast as Sarah Reese, a fourth-year medical student.

[45] On April 19, 2019, NBC announced that original cast member Colin Donnell and Norma Kuhling would be written out of the series at the end of the fourth season for creative reasons.

[46] On May 12, 2021, NBC announced that original cast members Yaya DaCosta and Torrey DeVitto would leave the series at the end of the sixth season after deciding not to renew their contracts to pursue new roles.

[47] On July 21, 2021, it was announced that Steven Weber would be promoted to a series regular after recurring in the sixth season, and Guy Lockard and Kristen Hager would join the main cast.

The site's critics consensus reads, "While adding nothing new to the established medical procedural formula, Dick Wolf's Chicago Med hits its familiar beats forcefully enough to satisfy a few genre enthusiasts.

[82] In Romania, the series debuted on February 16, 2017, on the channel Diva under the title "Camera de gardă" (The guard room).