Chicoreus brevifrons, common name the West Indian murex, is a species of predatory sea snail, a marine gastropod mollusk in the family Muricidae, the murex snails.

Three axial varices are present along its body whorl, and they are ornamented by characteristic expanded hollow spines.

C. brevifrons occurs in the Western Central Atlantic, from the Caribbean, the Gulf of Mexico, the Antilles to Brazil.

[2] This sea snail dwells on mud flats in protected bays and lagoons.

[3] This sea snail is locally collected for food, and is consumed raw or boiled.