He played on the early Giants teams under manager John McGraw and was the primary catcher for Hall of Famer Christy Mathewson.

Not wanting to complete a special program to be reinstated into Dartmouth, Meyers signed a baseball contract with an independent league.

Facing elimination against the Athletics in Game 6 of the 1911 World Series, Meyers' Giants trailed 6–1 entering the bottom of the seventh in Philadelphia.

After Chief Bender opened the frame with a flyout, two singles and an error by first baseman Fred Merkle fielding a throw on a sacrifice bunt made the score 7–1.

Two consecutive singles would score two further runs, then with runners at the corners, Harry Davis hit a 2–1 pitch into right-center to make it 10–1.

Future Hall of Famer Rube Marquard, who had gone 24–7 that year with a 2.50 ERA and a career-high 237 strikeouts, came into pitch with two runners in scoring position and his team down by ten.

After a "heated conference" between the battery mates near home plate, order ensued, but the next batter promptly singled off Marquard.

[3] Meyers was also a key player in that year's World Series versus the Boston Red Sox, which featured the infamous "Snodgrass Muff" as well as captivating performances by Mathewson and Smoky Joe Wood.

In only two years of playing Major League Baseball, Meyers teamed up with the great Christy Mathewson, putting on a sketch entitled "Curves", written by their co-star May Tully.

After getting replaced by Danny Murphy,[clarification needed] Meyers' last stop in baseball was catching for a semipro team in San Diego in 1920.

After getting booed at a semipro game, Meyers decided to quit baseball and became a police chief for the Mission Indian Agency.