The chief secretary Khyber Pakhtunkhwa (Urdu: مُعْتَمَدِ اعلٰی خیبر پختونخوا), also referred to as CS KP, is the bureaucratic chief and highest-ranking official of the Government of Khyber Pakhtunkhwa.

The appointment of the chief secretary is made directly by the prime minister of Pakistan.

The position of chief secretary is equivalent to the rank of federal secretary and the position holder usually belongs to the Pakistan Administrative Service.

The CS in turn reports to the chief minister, however the chief secretary is not under the charge of the chief minister as only the prime minister can appoint or remove the CS from his position.

The following table lists the names of chief secretaries who have remained in office since March 1997.