Chiesa Madre San Nicolò Vescovo, Melilli

San Nicolò Vescovo is a Renaissance-style Roman Catholic church located on Piazza Duomo, above Via Ruggero Settimo in the town of Melilli, province of Siracusa, region of Sicily, Italy.

In the very plain East-facing facade, the architrave of the portals have sculpted elements from the coat of arms of the Moncada family and symbols of the bishopric.

Interior to church is a ceiling fresco depicting the Triumph of the Faith (1762) by Olivio Sozzi.

The main altarpiece depicts a Glory of San Nicola (1769) by Francesco Gramignani Arezzi.

The chapel dedicated to the Madonna of Lourdes with an artificial grotto was built in 1819 under patronage of a local parishioner and using designs by Mario Moschetti.