In 2014, he pitched with the rookie-level Elizabethton Twins and Single-A Cedar Rapids Kernels, logging a cumulative 8–2 record and 2.15 ERA in 13 games, 12 of them starts.

[1] Hu began the 2015 season with the High-A Fort Myers Miracle, and also pitched in 1 game for the Triple-A Rochester Red Wings.

[2] On July 31, 2015, the Twins traded Hu and Alexis Tapia to the Tampa Bay Rays in exchange for Kevin Jepsen.

[7] On November 19, 2018, Hu was traded to the Cleveland Indians in exchange for minor league infielder Gionti Turner.

[10] He finished the year in Chicago's minor league system, posting a 2–2 record between the Triple–A Iowa Cubs and the Double–A Tennessee Smokies.

On February 14, 2024, it was announced that Hu would miss the first half of the season after undergoing surgery to remove bone spurs from his elbow.