Jeremy Smith, Barrister with the Victorian Bar, joined the board of the Children's Cancer Centre Foundation on 29 March 2009 and was elected Chairman later that year.

The campaign was initiated in 2002 with the support of high profile and influential business leaders; construction commenced in November 2004; and the new facilities were opened on 10 October 2006.

A new research initiative launched in 2017, the Hudson-Monash Paediatric Precision Medicine Program, aims to significantly improve treatment for children diagnosed with brain cancers and solid tumours.

The Foundation currently has commitments of $15 million across over 30 projects from 2019 through to 2024, funding salaries for 40 hospital and research staff, laboratory consumables and family resources.

[12] In addition to The Million Dollar Lunch, the Foundation raises funds through community fundraising, corporate partnerships, bequests and donations.