[1] The hospital treats infants, children, teens, and young adults aged 0–21.

Senator Frank Blair conversed with friends about the need for a hospital dedicated to the care of poor children.

[3] Blair encouraged her friends to support the hospital and a female Board of Managers was formed.

They supported the daily administration of the hospital and a "gentlemen's advisory board" was responsible for the financial and legal side.

After occupying the rented house for a year, the organization raised funds to buy a building on Franklin Avenue.

With accommodations limited to fifteen beds, patients with chronic, incurable, or infectious diseases were not admitted.

In the early 1900s, Washington University's Medical School was undergoing a re-working after receiving a poor rating during a review in 1909; the medical school was noted to be lacking in full-time faculty and dedicated teaching hospitals.

Today, St. Louis Children's Hospital's clinical and community outreach programs serve more than 250,000 patients annually.