Through a $250,000 bond issue, the original children's hospital was completed in 1929 in Chattanooga's Glenwood community.

[3] During the 1940s, the hospital pioneered new polio treatments, including hydrotherapy, and opened the region's first unit for premature babies.

With this change, hospital would continue to honor its founder by naming its downtown pediatric location, the "T.C.

The center represents phase one of plans for a new Children's Hospital, part of a multi-year re-imagining of Erlanger's downtown campus.

Children's Hospital physicians serve as the pediatrics department for the medical school, providing both specialty and subspecialty training.

In fiscal year 2023, Children's Hospital at Erlanger admitted 4,102 pediatric patients, performed 8,063 surgeries, and had 41,211 emergency room visits.