The regional pediatric healthcare network includes a 334-bed main hospital facility in the City of Orange, and a hospital-within-a-hospital in Mission Viejo.

[18][19][20] In November 2023, CHOC and Rady Children’s Hospital announced their intent to merge, aiming to form one of the largest pediatric healthcare systems in California.

[21] This significant step was approved by the California Attorney General in November 2024, clearing the way for both institutions to align clinical operations, research efforts, and community outreach strategies under a single network.

[22] According to representatives from CHOC and Rady Children’s, the merger seeks to enhance the delivery of specialized pediatric care, increase access for families across Southern California, and streamline administrative processes.

In 2017, the ED was the recipient of the Lantern Award from the Emergency Nurses Association for exceptional and innovative performance in leadership, practice, education, advocacy, and research.