[3] The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21[4][5] throughout Houston and surrounding regions.

Children's Memorial Hermann Hospital also sometimes treats adults that require pediatric care.

[6] CMHH also features an American College of Surgeons designated Level 1 Pediatric Trauma Center, 1 of 5 in the state.

The hospital is nationally recognized for The Fetal Center, a subspecialty center made up of maternal-fetal medicine specialists that perform in utero surgery to treat fetuses with birth defects inside the mother's womb before they are born.

Affiliated physicians performed the first in utero spina bifida surgery in Texas after the MOMS trial, an NICHD-sponsored study of prenatal and postnatal closure of myelomeningocele.