It begins at the western terminus of Avenida Libertador General Bernardo O'Higgins.

Shortly after its junction with Vespucio Norte Express, Route 68 narrows to two lanes in each direction.

Going westward, Route 68 descends into the Curacaví Valley and bypasses the small city of the same name.

The eastern road is named Variante Agua Santa and serves as access to the city of Viña del Mar.

The final stretch of Route 68, named Santos Ossa, makes a steep descent into Valparaíso.