Chile is one of participating countries in the Pan American Games, the largest multi-sport event in the Americas.

The Chilean Olympic Committee (COCH) is the National Olympic Committee for the country and the main organizer for its participation at the Pan American Games.

At those Games, Chile won 79 medals, being its most successful participation.

The largest amount of gold medals was reached in the 2019 Pan American Games, when Chilean athletes received a total of 13 gold medals.

Chile has hosted the Pan American Games once: Before 2023, Santiago was expected to host the Pan American Games on different occasions but the events were eventually cancelled: