It appears he was supposed to be but a tool in the hands of Ragenfrid, mayor of the palace of Neustria, acclaimed in 714 in opposition to Theudoald, Pepin of Heristal's designated heir.

In 716, he and Ragenfrid together led an army into Austrasia, then being warred over by Plectrude, on behalf of her grandson Theudoald, and Charles Martel, the son of Pepin of Heristal.

Thereafter, Charles Martel remained virtually undefeated and Chilperic's strong will was subdued in a series of campaigns waged in Neustrian territory.

In 718, Chilperic, in response, allied with Odo the Great, the Duke of Aquitaine, who had made himself independent during the contests in 715, but he was again defeated by Charles, at Soissons in 718.

In 719, Chilperic II was officially raised on the shield as King of all the Franks, but he survived but a year and his successors were mere rois fainéants.