Chiseldon village was provided with a station when the line opened as the Swindon, Marlborough and Andover Railway in 1881, and during the First World War a long siding was built from the station to the army establishment at Draycot Foliat which was later known as Chiseldon Camp.

In 1930, with the M&SWJR having been taken over by the Great Western Railway and with greater competition from road transport, a halt was opened on the main line itself about half a mile from the camp.

In the Second World War, American forces were stationed in large numbers at Chiseldon Camp, where they built a hospital.

The line was extensively used for military transportation, as it linked the Midlands to the south.

No trace of the station now remains; the trackbed is part of the National Cycle Network.