Ganesh draws from mythology, literature, and popular culture such as comics and anime to reveal feminist and queer narratives from the past and to imagine new visions of the future.
For the artist, "visual languages in Bollywood's orbit became conduits for expressing an expanded sense of the real, heightening the fantastical and symbolic via a hybrid use of graphics and paint.
"[4] Growing up in a diaspora community, Ganesh read Amar Chitra Katha (ACK), a celebrated comic series published in India, with a focus providing stories in religion, history, and myth to children and young adults.
Ganesh attended Saint Ann's School in Brooklyn and graduated in 1996 from Brown University Phi Beta Kappa with a BA in Comparative Literature and Art Semiotics.
[10][2] Ganesh is inspired by non-canonical narratives and figures, botched love stories, present-day imperialism, lesser-known Hindu/Buddhist icons, nineteenth-century European fairy tales, girl rock, and contemporary visual culture, such as Bollywood posters, anime, and comic books.
[11] Her early 24-page comic book, Tales of Amnesia (2002–2007), appropriates scenes from Amar Chitra Katha; the original work's male warrior heroes were replaced with women, through whom Ganesh offer new female subjectivities.
[14] Another project by Ganesh that sheds light on the construction of feminine iconography is Eyes of Time, a 4.5-by-12 ft multimedia mural conceived for the Brooklyn Museum in New York.
The artist explores the South Asian traditions of Saki, a divine female empowerment, and sacred Indian portrayals of the Greatest Goddess Kali.
She has held residencies at the Lower Manhattan Cultural Council, New York University, Headlands Center for the Arts, Smack Mellon Studios, and the Skowhegan School of Painting and Sculpture, among others.
[18] In 2024, Ganesh designed Coherence, a series of animated works in Penn Station's Moynihan Train Hall in New York, which further explores "femininity, sexuality, and power" through the emphasis on breathing practices.