[5] From June 15 to August 31, 2018, Choi (together with Everglow members Kim Si-hyeon and Wang Yiren) represented Yuehua Entertainment on reality girl group survival show Produce 48.

The group's debut extended play (EP) Color*Iz was released on October 29, 2018, with "La Vie en Rose" serving as its lead single.

[6][7][8] Following her debut with Iz*One, Choi became a cast member for Prison Life of Fools, alongside Got7's JB, Jang Do-yeon, Jeong Hyeong-don and many more.

[10] After Iz*One's disbandment in April 2021, Choi became a cast member of TVING's Idol Dictation Contest.

[11][12] She also joined the fixed MC panels for tvN Story's Fireworks Handsome and MBC's Game of Blood.

[13][14] On August 6, 2021, Choi was confirmed as the sole MC of Studio Waffle's web variety show Yena's Animal Detective.

[15] Choi made her acting debut later that year portraying Oh Na-ri in the second season of the web series The World of My 17.