He served as a coach for the Yankees, St. Louis Cardinals, New York Mets, Cincinnati Reds, and Seattle Mariners.

He was an All-Star with the Yankees in 1976, the same year he hit the series-winning home run in the 1976 American League Championship Series.

He was a member of the Yankees' 1977 and 1978 World Series championship teams, both against the Los Angeles Dodgers, and won the Gold Glove Award in 1978.

His father was a chaplain in the United States Navy, leading the family to relocate many times during Chris' childhood.

Chambliss was traded along with Dick Tidrow and Cecil Upshaw from the Indians to the New York Yankees for Fritz Peterson, Steve Kline, Fred Beene, and Tom Buskey on April 26, 1974.

[6] In the deciding Game 5 of the American League Championship Series against the Kansas City Royals, Chambliss hit Mark Littell's first pitch in the bottom of the ninth inning over the right field wall for a game-winning home run, giving the Yankees their first pennant since 1964.

Chambliss played three more seasons with the Yankees, helping lead them to the World Series title in 1977–their first in fifteen years–and winning a Gold Glove for his fielding prowess in 1978.

Immediately after that 1976 walk-off home run, thousands of fans stormed the Yankee Stadium field to celebrate.

Later, after I got to the clubhouse, [Graig] Nettles said I should return to the field and touch home plate, just to make it official.

However, the mayhem on the field made this task impossible, and given the magnitude of the game, Herzog would have never tried to have it restarted or protested due to a technicality.

[9] As a result of this incident, Major League Baseball changed the rules to allow the umpire to award any base runner or batter a run when he cannot reach the plate due to fans rushing the field.

After the 1979 season, the Yankees traded Chambliss to the Toronto Blue Jays with Damaso Garcia and Paul Mirabella for Rick Cerone, Tom Underwood, and Ted Wilborn.

[11] Later that offseason, the Blue Jays traded Chambliss with Luis Gómez to the Atlanta Braves for prospects Barry Bonnell, Joey McLaughlin, and Pat Rockett.

[22] Chambliss was the manager of the Triple A Charlotte Knights prior to joining the Seattle Mariners in November 2010 as hitting coach.