His professional career started when he joined Diz Watson, the renowned exponent of New Orleans blues/Professor Longhair-style piano and barrel house blues, as bass player.

[1][2][3][4] In 1982 Constantinou joined Adam Ant's live band as bass guitarist and backing vocalist in time for the Friend or Foe album tour and the video for the single Desperate But Not Serious.

Parting with Ant in 1985, Constantinou spent time with SF Go, a Miles Copeland III-managed band he had formed with Danny Kustow (TRB, Glen Matlock).

As lead singer, songwriter and bassist, JackieOnAssid toured Europe three times, released two albums (2001's 4Play and 2002's Zip Me Up) and supported Iggy Pop.

[2][8][13][14] A collaboration with Daler Mehndi in 2007 materialized in the Bhangra / rock single Two Eyes (Do Naina), which topped the BBC Asian Network charts.

[17] It materialized in the creation of the musical supergroup The Mutants, with Chris Constantinou and Paul Frazer as core members, later also joined by Rat Scabies.

After a series of initial projects (like Nuclear Wasteland, made at the disaster site in Chernobyl),[2][18] the first album, Rhythm and Punk Review, was released in July 2014.

[21] The third album, Your Desert My Mind (October 2016), is a collaboration with a series of guests from the Californian desert rock scene, among them David Catching from Eagles of Death Metal, Chris Goss from Masters of Reality, Brent DeBoer, Peter Holmström and Zia McCabe from The Dandy Warhols, Sean Wheeler from Throw Rag and Victoria Williams.

[40] In September 2020, they released the EP Like Wow and, in January 2021, the single Brand New Cadillac, noticed in reviews as an update with modern sonic textures of the 1959 classic rockabilly hit by Vince Taylor.